| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent dopamine transporter |
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| Ligand | BDBM50111882 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_62179 |
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| IC50 | 13±n/a nM |
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| Citation |  Davies, HM; Ren, P; Kong, NX; Sexton, T; Childers, SR Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters. Bioorg Med Chem Lett12:845-7 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent dopamine transporter |
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| Name: | Sodium-dependent dopamine transporter |
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| Synonyms: | DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 68749.45 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P23977 |
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| Residue: | 619 |
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| Sequence: | MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQER
ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC
NNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT
ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD
FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG
FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID
SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG
TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV
TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDH
QLVDRGEVRQFTLRHWLLL
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| BDBM50111882 |
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| n/a |
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| Name | BDBM50111882 |
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| Synonyms: | (E)-5-Iodo-1-(8-methyl-3-p-tolyl-8-aza-bicyclo[3.2.1]oct-2-yl)-pent-4-en-1-one | CHEMBL169320 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26INO |
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| Mol. Mass. | 423.331 |
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| SMILES | CN1C2CCC1C(C(C2)c1ccc(C)cc1)C(=O)CC\C=C\I |TLB:16:6:1:4.3,0:1:6.7.8:4.3| |
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| Structure | 
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