| Reaction Details |
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 | Report a problem with these data |
| Target | Pancreatic triacylglycerol lipase |
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| Ligand | BDBM50552236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2033898 (CHEMBL4688056) |
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| IC50 | 830±n/a nM |
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| Citation |  Huo, PC; Hu, Q; Shu, S; Zhou, QH; He, RJ; Hou, J; Guan, XQ; Tu, DZ; Hou, XD; Liu, P; Zhang, N; Liu, ZG; Ge, GB Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors. Bioorg Med Chem29:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pancreatic triacylglycerol lipase |
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| Name: | Pancreatic triacylglycerol lipase |
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| Synonyms: | LIPP_PIG | PL | PNLIP | PTL | Pancreatic lipase | Pancreatic triacylglycerol lipase |
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| Type: | Enzyme |
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| Mol. Mass.: | 50080.69 |
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| Organism: | Sus scrofa (Pig) |
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| Description: | P00591 |
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| Residue: | 450 |
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| Sequence: | SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTI
TNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQ
NIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAE
PCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQK
NILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPC
PSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSL
FGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASK
ITVERNDGKVYDFCSQETVREEVLLTLNPC
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| BDBM50552236 |
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| n/a |
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| Name | BDBM50552236 |
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| Synonyms: | CHEMBL4782276 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H55NO3 |
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| Mol. Mass. | 561.8375 |
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| SMILES | COc1cc(\C=C2/Cc3ccc(cc3C2=O)N(CCC(C)CCCC(C)C)CCC(C)CCCC(C)C)ccc1O |
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| Structure | 
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