| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50112486 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_49302 |
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| Ki | 0.560000±n/a nM |
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| Citation |  Wu, S; Guilford, WJ; Chou, YL; Griedel, BD; Liang, A; Sakata, S; Shaw, KJ; Trinh, L; Xu, W; Zhao, Z; Morrissey, MM Design and synthesis of aminophenol-based factor Xa inhibitors. Bioorg Med Chem Lett12:1307-10 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50112486 |
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| n/a |
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| Name | BDBM50112486 |
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| Synonyms: | 4-([3-(3-Carbamimidoyl-phenyl)-allyl]-{4-[1-(1-imino-ethyl)-piperidin-4-yloxy]-3-trifluoromethyl-phenyl}-carbamoyl)-phthalic acid | CHEMBL24263 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H32F3N5O6 |
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| Mol. Mass. | 651.6323 |
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| SMILES | CC(=N)N1CCC(CC1)Oc1ccc(cc1C(F)(F)F)N(C\C=C\c1cccc(c1)C(N)=N)C(=O)c1ccc(C(O)=O)c(c1)C(O)=O |
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| Structure | 
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