| Reaction Details |
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 | Report a problem with these data |
| Target | Cruzipain |
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| Ligand | BDBM50451633 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2045565 (CHEMBL4700264) |
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| Ki | 125893±n/a nM |
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| Citation |  Bonatto, V; Batista, PHJ; Cianni, L; De Vita, D; Silva, DG; Cedron, R; Tezuka, DY; de Albuquerque, S; Moraes, CB; Franco, CH; Lameira, J; Leitão, A; Montanari, CA On the intrinsic reactivity of highly potent trypanocidal cruzain inhibitors. RSC Med Chem11:1275-1284 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cruzipain |
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| Name: | Cruzipain |
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| Synonyms: | CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase |
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| Type: | Protein |
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| Mol. Mass.: | 49831.41 |
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| Organism: | Trypanosoma cruzi |
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| Description: | P25779 |
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| Residue: | 467 |
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| Sequence: | MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLS
VFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEV
VGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDK
TDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVEL
PQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYW
IIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSY
FVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVR
SSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
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| BDBM50451633 |
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| n/a |
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| Name | BDBM50451633 |
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| Synonyms: | CHEMBL4213366 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H28N2O5 |
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| Mol. Mass. | 436.5002 |
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| SMILES | CCOC(=O)\C=C\C1(CC1)NC(=O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1 |r| |
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| Structure | 
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