Reaction Details |
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Target | Cytochrome P450 3A4 |
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Ligand | BDBM50553250 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2045812 (CHEMBL4700511) |
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IC50 | 17500±n/a nM |
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Citation | Kirk, R; Ratcliffe, A; Noonan, G; Uosis-Martin, M; Lyth, D; Bardell-Cox, O; Massam, J; Schofield, P; Lyons, A; Clare, D; Maclean, J; Smith, A; Savage, V; Mohmed, S; Charrier, C; Salisbury, AM; Moyo, E; Ooi, N; Chalam-Judge, N; Cheung, J; Stokes, NR; Best, S; Craighead, M; Armer, R; Huxley, A Rational design, synthesis and testing of novel tricyclic topoisomerase inhibitors for the treatment of bacterial infections part 2. RSC Med Chem11:1379-1385 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 3A4 |
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Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 57349.57 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 503 |
Sequence: | MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMF
DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISI
AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICV
FPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSI
IFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVV
NETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFS
KKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLG
GLLQPEKPVVLKVESRDGTVSGA
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BDBM50553250 |
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n/a |
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Name | BDBM50553250 |
Synonyms: | CHEMBL4786331 |
Type | Small organic molecule |
Emp. Form. | C20H22ClFN4O2 |
Mol. Mass. | 404.866 |
SMILES | [H][C@]1(CCN(C1)c1c(F)cc2c3oc(C)nc3c(=O)n(C3CC3)c2c1Cl)[C@H](C)N |r| |
Structure |
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