Ki Summary

Reaction Details

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Target

Alpha-synuclein

Ligand

BDBM50017543

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2045854 (CHEMBL4700553)

IC50

7900±n/a nM

Citation

Oliveri, V Toward the discovery and development of effective modulators of ?-synuclein amyloid aggregation. Eur J Med Chem167:10-36 (2019) [PubMed] Article

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Get all data from this article, Assay Method

Alpha-synuclein

Name:

Alpha-synuclein

Synonyms:

NACP | PARK1 | SNCA | SYUA_HUMAN

Type:

Protein

Mol. Mass.:

14451.42

Organism:

Homo sapiens (Human)

Description:

P37840

Residue:

140

Sequence:

MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVATVAEKTK
EQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDP
DNEAYEMPSEEGYQDYEPEA

BDBM50017543

n/a

Name

BDBM50017543

Synonyms:

(6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-7-ium | (6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline | 5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-amide | 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-7-ium(Pergolide) | 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline | 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline(pergolide) | 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline, mesylate (Pergolide) | CHEMBL531 | PERGOLIDE | Permax | [2-(1H-Indol-4-yl)-ethyl]-methyl-amine | cid_47811

Type

Small organic molecule

Emp. Form.

C19H26N2S

Mol. Mass.

314.488

SMILES

CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3cccc2c13 |r|

Structure