| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50114821 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_87852 (CHEMBL701992) |
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| IC50 | 9.5±n/a nM |
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| Citation |  Woo, SH; Frechette, S; Abou Khalil, E; Bouchain, G; Vaisburg, A; Bernstein, N; Moradei, O; Leit, S; Allan, M; Fournel, M; Trachy-Bourget, MC; Li, Z; Besterman, JM; Delorme, D Structurally simple trichostatin A-like straight chain hydroxamates as potent histone deacetylase inhibitors. J Med Chem45:2877-85 (2002) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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|
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| BDBM50114821 |
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| n/a |
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| Name | BDBM50114821 |
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| Synonyms: | 8-Oxo-8-(4-piperidin-1-yl-phenyl)-octanoic acid hydroxyamide | CHEMBL99877 | N-hydroxy-8-oxo-8-(4-(piperidin-1-yl)phenyl)octanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N2O3 |
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| Mol. Mass. | 332.4372 |
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| SMILES | ONC(=O)CCCCCCC(=O)c1ccc(cc1)N1CCCCC1 |
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| Structure | 
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