Reaction Details |
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Target | Delta-type/Mu-type opioid receptor |
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Ligand | BDBM21015 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2050540 (CHEMBL4705239) |
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EC50 | 2.7±n/a nM |
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Citation | Faouzi, A; Uprety, R; Gomes, I; Massaly, N; Keresztes, AI; Le Rouzic, V; Gupta, A; Zhang, T; Yoon, HJ; Ansonoff, M; Allaoa, A; Pan, YX; Pintar, J; Morón, JA; Streicher, JM; Devi, LA; Majumdar, S Synthesis and Pharmacology of a Novel ?-? Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. J Med Chem63:13618-13637 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type/Mu-type opioid receptor |
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Name: | Delta-type/Mu-type opioid receptor |
Synonyms: | Opioid receptors; mu and delta |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 851397 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Delta-type opioid receptor |
Synonyms: | DOR-1 | K56 | MSL-2 | OPIATE Delta | OPRD_MOUSE | Opioid receptors; mu and delta | Oprd1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 40577.25 |
Organism: | MOUSE |
Description: | P32300 |
Residue: | 372 |
Sequence: | MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTAC
TPSDGPGGGAAA
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Component 2 |
Name: | Mu-type opioid receptor |
Synonyms: | M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 44431.62 |
Organism: | MOUSE |
Description: | OPIATE Mu OPRM1 MOUSE::P42866 |
Residue: | 398 |
Sequence: | MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQT
GSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATST
LPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRT
PRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFA
FIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV
IIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQ
QNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
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BDBM21015 |
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n/a |
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Name | BDBM21015 |
Synonyms: | (2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]-N-methylacetamido}-N-(2-hydroxyethyl)-3-phenylpropanamide | 2-Ala-4-MePhe-5-Gly-Enkephalin | CHEMBL38874 | D-Ala2-MePhe4-Met(0)5-enkephalin-ol | DAMGO | RX 783006 | US11492374, ID 2 | US11912716, Compound DAMGO | US20240092802, Compound DAMGO | [3H]DAMGO | [tyrosyl-3,5-3H(N)]-D-Ala2-Mephe4-glyol5-enkephalin |
Type | Analgesics |
Emp. Form. | C26H35N5O6 |
Mol. Mass. | 513.586 |
SMILES | C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO |
Structure |
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