Reaction Details |
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Target | Cathepsin D |
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Ligand | BDBM50555216 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2051503 (CHEMBL4706202) |
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IC50 | 127±n/a nM |
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Citation | Goyal, S; Patel, KV; Nagare, Y; Raykar, DB; Raikar, SS; Dolas, A; Khurana, P; Cyriac, R; Sarak, S; Gangar, M; Agarwal, AK; Kulkarni, A Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D. Bioorg Med Chem29:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin D |
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Name: | Cathepsin D |
Synonyms: | CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor |
Type: | Enzyme |
Mol. Mass.: | 44551.72 |
Organism: | Homo sapiens (Human) |
Description: | Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated. |
Residue: | 412 |
Sequence: | MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
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BDBM50555216 |
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n/a |
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Name | BDBM50555216 |
Synonyms: | CHEMBL4755672 |
Type | Small organic molecule |
Emp. Form. | C25H32F3N5O8S2 |
Mol. Mass. | 651.675 |
SMILES | OC(=O)C(F)(F)F.COc1ccc(CC(=O)NC(=N)N[C@H](CCSC)C(=O)Nc2cc(ccc2C)S(N)(=O)=O)cc1OC |r| |
Structure |
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