| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmin |
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| Ligand | BDBM50555440 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2052002 (CHEMBL4707003) |
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| IC50 | 198±n/a nM |
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| Citation |  Jiang, F; Wang, HJ; Jin, YH; Zhang, Q; Wang, ZH; Jia, JM; Liu, F; Wang, L; Bao, QC; Li, DD; You, QD; Xu, XL Novel Tetrahydropyrido[4,3-d]pyrimidines as Potent Inhibitors of Chaperone Heat Shock Protein 90. J Med Chem59:10498-10519 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmin |
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| Name: | Endoplasmin |
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| Synonyms: | 94 kDa glucose-regulated protein | ENPL_HUMAN | GRP-94 | GRP94 | Glucose regulated protein 94kDa (Grp94) | HSP90B1 | Heat shock protein 90 kDa beta member 1 | TRA1 | Tumor rejection antigen 1 | gp96 homolog |
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| Type: | Protein |
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| Mol. Mass.: | 92417.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14625 |
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| Residue: | 803 |
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| Sequence: | MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDG
LNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISL
TDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTE
AQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNT
LGRGTTITLVLKEEASDYLELDTIKNLVKKYSQFINFPIYVWSSKTETVEEPMEEEEAAK
EEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYK
SFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITD
DFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADDKY
NDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHPTDITSLDQYVERMKEKQDKIYF
MAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDE
SEKTKESREAVEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMER
IMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVLDLAVVLFET
ATLRSGYLLPDTKAYGDRIERMLRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDE
EMDVGTDEEEETAKESTAEKDEL
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| BDBM50555440 |
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| n/a |
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| Name | BDBM50555440 |
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| Synonyms: | CHEMBL4797602 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25N3O5 |
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| Mol. Mass. | 387.4296 |
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| SMILES | COCCOc1ncc2CN(CCc2n1)C(=O)c1cc(C(C)C)c(O)cc1O |
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| Structure | 
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