| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aldehyde dehydrogenase, mitochondrial |
|---|
| Ligand | BDBM50555621 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2053026 (CHEMBL4708027) |
|---|
| IC50 | 1809±n/a nM |
|---|
| Citation |  Dinavahi, SS; Gowda, R; Bazewicz, CG; Battu, MB; Lin, JM; Chitren, RJ; Pandey, MK; Amin, S; Robertson, GP; Gowda, K Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem187:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aldehyde dehydrogenase, mitochondrial |
|---|
| Name: | Aldehyde dehydrogenase, mitochondrial |
|---|
| Synonyms: | ALDH class 2 | ALDH-E2 | ALDH2 | ALDH2_HUMAN | ALDHI | ALDM | Aldehyde dehydrogenase (ALDH2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56382.67 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05091 |
|---|
| Residue: | 517 |
|---|
| Sequence: | MLRAAARFGPRLGRRLLSAAATQAVPAPNQQPEVFCNQIFINNEWHDAVSRKTFPTVNPS
TGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLA
ALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCG
QIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPG
FGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADM
DWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGP
QVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEIFGP
VMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFGAQS
PFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
|
|
|
|---|
| BDBM50555621 |
|---|
| n/a |
|---|
| Name | BDBM50555621 |
|---|
| Synonyms: | CHEMBL4752256 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H14BrCl2N3O2Se |
|---|
| Mol. Mass. | 522.08 |
|---|
| SMILES | Br.[#7]-[#6](=[#7])[Se;v2][#6]-c1ccc(-[#6]-[#7]-2-[#6](=O)-[#6](=O)-c3cc(Cl)cc(Cl)c-23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
