| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Fructose-1,6-bisphosphatase 1 |
|---|
| Ligand | BDBM50414927 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2053890 (CHEMBL4708891) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Xu, YX; Huang, YY; Song, RR; Ren, YL; Chen, X; Zhang, C; Mao, F; Li, XK; Zhu, J; Ni, SS; Wan, J; Li, J Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem203:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Fructose-1,6-bisphosphatase 1 |
|---|
| Name: | Fructose-1,6-bisphosphatase 1 |
|---|
| Synonyms: | D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 36843.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Liver FBPase (P09467) |
|---|
| Residue: | 338 |
|---|
| Sequence: | MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
|
|
|
|---|
| BDBM50414927 |
|---|
| n/a |
|---|
| Name | BDBM50414927 |
|---|
| Synonyms: | CHEMBL582931 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H22N2S3 |
|---|
| Mol. Mass. | 278.501 |
|---|
| SMILES | CCN(CC)C(=S)CSC(=S)N(CC)CC |
|---|
| Structure | 
|
|---|
Search and Browse
