Reaction Details |
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Target | Coagulation factor XII |
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Ligand | BDBM50180541 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2055299 (CHEMBL4710300) |
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IC50 | 6000±n/a nM |
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Citation | Davoine, C; Bouckaert, C; Fillet, M; Pochet, L Factor XII/XIIa inhibitors: Their discovery, development, and potential indications. Eur J Med Chem208:0 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor XII |
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Name: | Coagulation factor XII |
Synonyms: | Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | Coagulation factor XII (FXII) | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | FA12_HUMAN | Factor XIIa | Factor XIIa (fXIIa) | HAF | Hageman factor |
Type: | Enzyme |
Mol. Mass.: | 67810.07 |
Organism: | Homo sapiens (Human) |
Description: | P00748 |
Residue: | 615 |
Sequence: | MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS
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BDBM50180541 |
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n/a |
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Name | BDBM50180541 |
Synonyms: | 4-guanidinophenyl 6-(chloromethyl)-2-oxo-2H-chromene-3-carboxylate | CHEMBL205702 |
Type | Small organic molecule |
Emp. Form. | C18H14ClN3O4 |
Mol. Mass. | 371.774 |
SMILES | [#7]\[#6](-[#7])=[#7]\c1ccc(-[#8]-[#6](=O)-c2cc3cc(-[#6]Cl)ccc3oc2=O)cc1 |
Structure |
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