Reaction Details |
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Target | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Ligand | BDBM50118581 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_212264 (CHEMBL816289) |
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IC50 | >336000±n/a nM |
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Citation | Pirrung, MC; Tumey, LN; Raetz, CR; Jackman, JE; Snehalatha, K; McClerren, AL; Fierke, CA; Gantt, SL; Rusche, KM Inhibition of the antibacterial target UDP-(3-O-acyl)-N-acetylglucosamine deacetylase (LpxC): isoxazoline zinc amidase inhibitors bearing diverse metal binding groups. J Med Chem45:4359-70 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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UDP-3-O-acyl-N-acetylglucosamine deacetylase |
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Name: | UDP-3-O-acyl-N-acetylglucosamine deacetylase |
Synonyms: | LPXC_ECOLI | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LxpC) | UDP-3-O-acyl-GlcNAc deacetylase | asmB | envA | lpxC |
Type: | Enzyme |
Mol. Mass.: | 33952.00 |
Organism: | Escherichia coli |
Description: | P0A725 |
Residue: | 305 |
Sequence: | MIKQRTLKRIVQATGVGLHTGKKVTLTLRPAPANTGVIYRRTDLNPPVDFPADAKSVRDT
MLCTCLVNEHDVRISTVEHLNAALAGLGIDNIVIEVNAPEIPIMDGSAAPFVYLLLDAGI
DELNCAKKFVRIKETVRVEDGDKWAEFKPYNGFSLDFTIDFNHPAIDSSNQRYAMNFSAD
AFMRQISRARTFGFMRDIEYLQSRGLCLGGSFDCAIVVDDYRVLNEDGLRFEDEFVRHKM
LDAIGDLFMCGHNIIGAFTAYKSGHALNNKLLQAVLAKQEAWEYVTFQDDAELPLAFKAP
SAVLA
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BDBM50118581 |
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n/a |
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Name | BDBM50118581 |
Synonyms: | (R/S)-3-(4-Methoxy-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid pyridin-2-ylamide | CHEMBL136474 |
Type | Small organic molecule |
Emp. Form. | C16H15N3O3 |
Mol. Mass. | 297.3086 |
SMILES | COc1ccc(cc1)C1=NOC(C1)C(=O)Nc1ccccn1 |t:9| |
Structure |
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