| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
|---|
| Ligand | BDBM388642 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2059157 (CHEMBL4714158) |
|---|
| Ki | 39±n/a nM |
|---|
| Citation |  Díaz, JL; Cuevas, F; Pazos, G; Álvarez-Bercedo, P; Oliva, AI; Sarmentero, MÁ; Font, D; Jiménez-Aquino, A; Morón, M; Port, A; Pascual, R; Dordal, A; Portillo-Salido, E; Reinoso, RF; Vela, JM; Almansa, C Bicyclic Diazepinones as Dual Ligands of the ?2?-1 Subunit of Voltage-Gated Calcium Channels and the Norepinephrine Transporter. J Med Chem64:2167-2185 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium-dependent noradrenaline transporter |
|---|
| Name: | Sodium-dependent noradrenaline transporter |
|---|
| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69337.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P23975 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
|
|
|
|---|
| BDBM388642 |
|---|
| n/a |
|---|
| Name | BDBM388642 |
|---|
| Synonyms: | Reboxe- tine | US9944618, Compound ID No. 178 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H23NO3 |
|---|
| Mol. Mass. | 313.3908 |
|---|
| SMILES | CCOc1ccccc1O[C@@H]([C@H]1CNCCO1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
