Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM139041 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2060586 (CHEMBL4715587) |
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Ki | 0.430000±n/a nM |
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Citation | Tao, ZF; Wang, X; Chen, J; Ingram, JP; Jin, S; Judge, RA; Kovar, PJ; Park, C; Sun, C; Wakefield, BD; Zhou, L; Zhang, H; Elmore, SW; Phillips, DC; Judd, AS; Leverson, JD; Souers, AJ Structure-Based Design of A-1293102, a Potent and Selective BCL-X ACS Med Chem Lett12:1011-1016 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM139041 |
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n/a |
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Name | BDBM139041 |
Synonyms: | US8883784, 2 |
Type | Small organic molecule |
Emp. Form. | C42H40F3N7O7S5 |
Mol. Mass. | 972.13 |
SMILES | FC(F)(F)S(=O)(=O)c1cc(ccc1N[C@H](CCN1CCOCC1)CSc1ccccc1)S(=O)(=O)NC(=O)c1csc(n1)N1CCc2cccc(C(=O)Nc3nc4ccccc4s3)c2C1 |
Structure |
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