Ki Summary

Reaction Details

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Target

Muscarinic acetylcholine receptor M1

Ligand

BDBM50557934

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2060789 (CHEMBL4716042)

1.6±n/a nM

Citation

Gruber, CG; Pegoli, A; M�ller, C; Gr�tz, L; She, X; Keller, M Differently fluorescence-labelled dibenzodiazepinone-type muscarinic acetylcholine receptor ligands with high M RSC Med Chem11:823-832 (2020) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Muscarinic acetylcholine receptor M1

Name:

Muscarinic acetylcholine receptor M1

Synonyms:

ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1

Type:

Protein

Mol. Mass.:

51442.54

Organism:

Homo sapiens (Human)

Description:

P11229

Residue:

460

Sequence:

MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC

BDBM50557934

n/a

Name

BDBM50557934

Synonyms:

CHEMBL4794548

Type

Small organic molecule

Emp. Form.

C49H53N7O12S3

Mol. Mass.

1028.18

SMILES

Cc1scc2c1N(C(=O)CN1CCN(CCCCCCCCCCNC(=O)c3ccc(c(c3)C(O)=O)-c3c4ccc(N)c(c4oc4c(c(=N)ccc34)S(O)(=O)=O)S(O)(=O)=O)CC1)c1ccccc1NC2=O |(36.93,-9.73,;38.19,-8.84,;39.64,-9.34,;40.57,-8.11,;39.69,-6.85,;38.21,-7.3,;36.93,-6.44,;35.6,-7.21,;35.6,-8.75,;34.27,-6.44,;32.93,-7.21,;32.93,-8.75,;31.6,-9.52,;30.26,-8.75,;28.93,-9.52,;27.6,-8.76,;26.27,-9.53,;24.93,-8.77,;23.6,-9.54,;22.26,-8.77,;20.93,-9.55,;19.6,-8.78,;18.27,-9.56,;16.93,-8.79,;15.6,-9.57,;15.6,-11.12,;16.95,-11.89,;14.27,-11.9,;12.92,-11.13,;11.59,-11.91,;11.58,-13.46,;12.93,-14.23,;14.27,-13.46,;12.93,-15.78,;14.27,-16.56,;12.51,-17.27,;10.25,-14.22,;10.25,-15.77,;11.58,-16.55,;11.58,-18.09,;10.24,-18.86,;10.23,-20.41,;8.9,-18.09,;8.9,-16.54,;7.56,-15.76,;7.57,-14.21,;6.26,-13.45,;6.26,-11.92,;4.92,-11.13,;7.59,-11.14,;8.92,-11.93,;8.91,-13.46,;4.91,-14.21,;3.57,-13.44,;5.74,-15.5,;4.13,-15.54,;7.54,-18.84,;6.22,-18.07,;8.31,-20.18,;6.77,-20.18,;30.26,-7.21,;31.6,-6.44,;36.83,-4.92,;35.36,-4.47,;35.01,-2.98,;36.14,-1.92,;37.61,-2.37,;37.95,-3.87,;39.48,-4.08,;40.24,-5.42,;41.78,-5.3,)|

Structure