Reaction Details |
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Target | 5-hydroxytryptamine receptor 1A |
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Ligand | BDBM50558346 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2063306 (CHEMBL4718559) |
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Ki | 213±n/a nM |
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Citation | Stefanowicz, J; S?owi?ski, T; Wróbel, MZ; Herold, F; Gomó?ka, AE; Weso?owska, A; Jastrz?bska-Wi?sek, M; Partyka, A; Andres-Mach, M; Czuczwar, SJ; ?uszczki, JJ; Zagaja, M; Siwek, A; Nowak, G; ?o?nierek, M; B?czek, T; Ulenberg, S; Belka, M; Tur?o, J Synthesis and biological investigation of new equatorial (?) stereoisomers of 3-aminotropane arylamides with atypical antipsychotic profile. Bioorg Med Chem24:3994-4007 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 1A |
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Name: | 5-hydroxytryptamine receptor 1A |
Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46445.29 |
Organism: | Rattus norvegicus (rat) |
Description: | Binding assays were performed using rat hippocampal membranes. |
Residue: | 422 |
Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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BDBM50558346 |
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n/a |
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Name | BDBM50558346 |
Synonyms: | CHEMBL4746049 |
Type | Small organic molecule |
Emp. Form. | C26H28N2O2 |
Mol. Mass. | 400.5127 |
SMILES | COc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1 |TLB:7:8:14.15.13:10.11| |
Structure |
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