Reaction Details |
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Target | 5-hydroxytryptamine receptor 2A |
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Ligand | BDBM50120936 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2666 (CHEMBL617914) |
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Ki | 303±n/a nM |
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Citation | Liégeois, JF; Eyrolles, L; Ellenbroek, BA; Lejeune, C; Carato, P; Bruhwyler, J; Géczy, J; Damas, J; Delarge, J New pyridobenzodiazepine derivatives: modifications of the basic side chain differentially modulate binding to dopamine (D(4.2), D(2L)) and serotonin (5-HT(2A)) receptors. J Med Chem45:5136-49 (2002) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 2A |
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Name: | 5-hydroxytryptamine receptor 2A |
Synonyms: | 5-HT-2A | 5-HT2 | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_RAT | Htr2 | Htr2a | Serotonin Receptor 2A |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 52852.05 |
Organism: | Rattus norvegicus (rat) |
Description: | Rat cortex membranes 5-HT2A receptors. |
Residue: | 471 |
Sequence: | MEILCEDNISLSSIPNSLMQLGDGPRLYHNDFNSRDANTSEASNWTIDAENRTNLSCEGY
LPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAIWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGA
LLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPALAYK
SSQLQVGQKKNSQEDAEQTVDDCSMVTLGKQQSEENCTDNIETVNEKVSCV
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BDBM50120936 |
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n/a |
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Name | BDBM50120936 |
Synonyms: | 8-Methyl-6-(4-methyl-[1,4]diazepan-1-yl)-11H-benzo[e]pyrido[3,2-b][1,4]diazepine | CHEMBL356171 |
Type | Small organic molecule |
Emp. Form. | C19H23N5 |
Mol. Mass. | 321.4194 |
SMILES | CN1CCCN(CC1)C1=Nc2cccnc2Nc2ccc(C)cc12 |t:9| |
Structure |
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