| Reaction Details |
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 | Report a problem with these data |
| Target | Cytoplasmic tyrosine-protein kinase BMX |
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| Ligand | BDBM50559921 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2070660 (CHEMBL4726194) |
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| IC50 | 12±n/a nM |
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| Citation |  de Bruin, G; Demont, D; de Zwart, E; Verkaik, S; Hoogenboom, N; van de Kar, B; van Lith, B; Emmelot-van Hoek, M; Gulrajani, M; Covey, T; Kaptein, A; Barf, T Discovery of quinoline-based irreversible BTK inhibitors. Bioorg Med Chem Lett30:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytoplasmic tyrosine-protein kinase BMX |
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| Name: | Cytoplasmic tyrosine-protein kinase BMX |
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| Synonyms: | BMX | BMX non-receptor tyrosine kinase | BMX_HUMAN | Bone marrow tyrosine kinase gene in chromosome X protein | Cytoplasmic tyrosine-protein kinase BMX (BMX) | ETK | Epithelial and endothelial tyrosine kinase | NTK38 | Tyrosine Kinase BMX | Tyrosine-protein kinase BMX/ETK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 78030.42 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51813 |
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| Residue: | 675 |
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| Sequence: | MDTKSILEELLLKRSQQKKKMSPNNYKERLFVLTKTNLSYYEYDKMKRGSRKGSIEIKKI
RCVEKVNLEEQTPVERQYPFQIVYKDGLLYVYASNEESRSQWLKALQKEIRGNPHLLVKY
HSGFFVDGKFLCCQQSCKAAPGCTLWEAYANLHTAVNEEKHRVPTFPDRVLKIPRAVPVL
KMDAPSSSTTLAQYDNESKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYIPREDF
PDWWQVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGN
ISRSQSEQLLRQKGKEGAFMVRNSSQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLY
LAENYCFDSIPKLIHYHQHNSAGMITRLRHPVSTKANKVPDSVSLGNGIWELKREEITLL
KELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCS
KEYPIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAAR
NCLVDRDLCVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGI
LMWEVFSLGKQPYDLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQ
QLLSSIEPLREKDKH
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| BDBM50559921 |
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| n/a |
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| Name | BDBM50559921 |
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| Synonyms: | CHEMBL4755977 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H29N5O5 |
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| Mol. Mass. | 551.5925 |
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| SMILES | COc1cc2nccc(Oc3ccc(cc3)C(=O)Nc3ccccn3)c2cc1NC(=O)C#CCCN1CCOCC1 |
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| Structure | 
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