Reaction Details |
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Target | Histone deacetylase 6 |
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Ligand | BDBM50380399 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2074032 (CHEMBL4729566) |
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IC50 | 4.4±n/a nM |
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Citation | Noonepalle, S; Shen, S; Ptá?ek, J; Tavares, MT; Zhang, G; Stránský, J; Pavlí?ek, J; Ferreira, GM; Hadley, M; Pelaez, G; Ba?inka, C; Kozikowski, AP; Villagra, A Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models. J Med Chem63:10246-10262 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 6 |
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Name: | Histone deacetylase 6 |
Synonyms: | Cereblon/Histone deacetylase 6 | HD6 | HDAC6 | HDAC6_HUMAN | Histone deacetylase 6 (HDAC6) | Human HDAC6 | KIAA0901 | ORF Names:JM21 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 131381.51 |
Organism: | Homo sapiens (Human) |
Description: | Q9UBN7 |
Residue: | 1215 |
Sequence: | MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLG
QAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLI
QEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNS
YSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQ
KHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQG
QGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATP
AGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSA
QASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSR
TGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCH
SAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLN
GAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMF
EDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWH
RLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEG
GYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVE
DREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSET
AVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGA
ILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQ
TPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEA
AGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQ
ENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKN
IAHQNKFGEDMPHPH
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BDBM50380399 |
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n/a |
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Name | BDBM50380399 |
Synonyms: | CHEMBL2018302 | Tubastatin A | US10227295, Compound Tubastatin A | US10456394, Tubastatin A | US11207431, Example D | US8748451, 6 | US9249087, Tubacin | US9751832, Tubastatin A | US9956192, Compound Tubastatin-A |
Type | Small organic molecule |
Emp. Form. | C20H21N3O2 |
Mol. Mass. | 335.3996 |
SMILES | CN1CCc2c(C1)c1ccccc1n2Cc1ccc(cc1)C(=O)NO |
Structure |
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