Reaction Details |
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Target | Histone deacetylase 2 |
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Ligand | BDBM50398716 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2074036 (CHEMBL4729570) |
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IC50 | 276±n/a nM |
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Citation | Noonepalle, S; Shen, S; Ptá?ek, J; Tavares, MT; Zhang, G; Stránský, J; Pavlí?ek, J; Ferreira, GM; Hadley, M; Pelaez, G; Ba?inka, C; Kozikowski, AP; Villagra, A Rational Design of Suprastat: A Novel Selective Histone Deacetylase 6 Inhibitor with the Ability to Potentiate Immunotherapy in Melanoma Models. J Med Chem63:10246-10262 (2020) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2 |
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Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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BDBM50398716 |
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n/a |
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Name | BDBM50398716 |
Synonyms: | CHEMBL2179618 | US10227295, Compound 5g | US9409858, 5g | US9751832, Compound 5g | US9956192, Compound 5g |
Type | Small organic molecule |
Emp. Form. | C19H23N3O3 |
Mol. Mass. | 341.4042 |
SMILES | CCCCN(Cc1ccc(cc1)C(=O)NO)C(=O)Nc1ccccc1 |
Structure |
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