Reaction Details |
| Report a problem with these data |
Target | Histone deacetylase 1 |
---|
Ligand | BDBM50123968 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_87856 (CHEMBL877713) |
---|
IC50 | 4000±n/a nM |
---|
Citation | Bouchain, G; Leit, S; Frechette, S; Khalil, EA; Lavoie, R; Moradei, O; Woo, SH; Fournel, M; Yan, PT; Kalita, A; Trachy-Bourget, MC; Beaulieu, C; Li, Z; Robert, MF; MacLeod, AR; Besterman, JM; Delorme, D Development of potential antitumor agents. Synthesis and biological evaluation of a new set of sulfonamide derivatives as histone deacetylase inhibitors. J Med Chem46:820-30 (2003) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histone deacetylase 1 |
---|
Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
|
|
|
BDBM50123968 |
---|
n/a |
---|
Name | BDBM50123968 |
Synonyms: | CHEMBL166883 | N-(2-Amino-phenyl)-3-[6-(biphenyl-4-sulfonylamino)-pyridin-3-yl]-acrylamide | US8796330, 86 |
Type | Small organic molecule |
Emp. Form. | C26H22N4O3S |
Mol. Mass. | 470.543 |
SMILES | Nc1ccccc1NC(=O)\C=C\c1ccc(NS(=O)(=O)c2ccc(cc2)-c2ccccc2)nc1 |
Structure |
|