| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacylase sirtuin-6 |
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| Ligand | BDBM50561913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2076228 (CHEMBL4731762) |
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| IC50 | >83000±n/a nM |
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| Citation |  Hong, JY; Jing, H; Price, IR; Cao, J; Bai, JJ; Lin, H Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy. ACS Med Chem Lett11:2305-2311 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacylase sirtuin-6 |
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| Name: | NAD-dependent protein deacylase sirtuin-6 |
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| Synonyms: | NAD-dependent protein deacetylase sirtuin-6 | NAD-dependent protein deacetylase sirtuin-6 (SIRT6) | Regulatory protein SIR2 homolog 6 | SIR2-like protein 6 | SIR2L6 | SIR6_HUMAN | SIRT6 | Sirtuin-6 (SIRT6) |
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| Type: | Protein |
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| Mol. Mass.: | 39133.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8N6T7 |
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| Residue: | 355 |
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| Sequence: | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTASG
IPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHV
RSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGE
LRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVN
LQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPK
EESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS
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| BDBM50561913 |
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| n/a |
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| Name | BDBM50561913 |
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| Synonyms: | CHEMBL4762508 |
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| Type | Small organic molecule |
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| Emp. Form. | C50H74N6O10S |
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| Mol. Mass. | 951.222 |
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| SMILES | CCCCCCCCCCCCCC(=S)NCCCC[C@H](NC(=O)CCOCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12)C(=O)Nc1ccccc1 |r| |
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| Structure | 
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