| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50562483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2078806 (CHEMBL4734597) |
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| IC50 | 5500±n/a nM |
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| Citation |  Relitti, N; Saraswati, AP; Chemi, G; Brindisi, M; Brogi, S; Herp, D; Schmidtkunz, K; Saccoccia, F; Ruberti, G; Ulivieri, C; Vanni, F; Sarno, F; Altucci, L; Lamponi, S; Jung, M; Gemma, S; Butini, S; Campiani, G Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation. Eur J Med Chem212:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50562483 |
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| n/a |
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| Name | BDBM50562483 |
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| Synonyms: | CHEMBL4782170 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H24N2O4 |
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| Mol. Mass. | 476.5226 |
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| SMILES | ONC(=O)c1ccc(Cn2c3ccccc3c(-c3ccccc3)c(OCc3ccccc3)c2=O)cc1 |
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| Structure | 
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