Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
---|
Ligand | BDBM50562613 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2079583 (CHEMBL4735374) |
---|
IC50 | 8.0±n/a nM |
---|
Citation | Dreas, A; Kucwaj-Brysz, K; Pyziak, K; Kulesza, U; Wincza, E; Fabritius, CH; Michalik, K; Gabor-Worwa, E; Go?as, A; Milik, M; Masiejczyk, M; Majewska, E; Py?niak, K; Wójcik-Trechci?ska, U; Sandowska-Markiewicz, Z; Brzózka, K; Ostrowski, J; Rzymski, T; Mikula, M Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock. Eur J Med Chem213:0 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
MAP kinase-interacting serine/threonine-protein kinase 2 |
---|
Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
Type: | Protein |
Mol. Mass.: | 51870.79 |
Organism: | Homo sapiens (Human) |
Description: | Q9HBH9 |
Residue: | 465 |
Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
|
|
|
BDBM50562613 |
---|
n/a |
---|
Name | BDBM50562613 |
Synonyms: | CHEMBL4785028 |
Type | Small organic molecule |
Emp. Form. | C21H19N5O2 |
Mol. Mass. | 373.4079 |
SMILES | CC(=O)Nc1cccc(Cn2cc(ccc2=O)-c2ccc3c(N)n[nH]c3c2)c1 |
Structure |
|