| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium- and chloride-dependent GABA transporter 2 |
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| Ligand | BDBM50039248 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2086313 (CHEMBL4767576) |
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| IC50 | 5129±n/a nM |
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| Citation |  Zar?ba, P; Gryz?o, B; Malawska, K; Sa?at, K; Höfner, GC; Nowaczyk, A; Fija?kowski, ?; Rapacz, A; Podkowa, A; Furga?a, A; ?mudzki, P; Wanner, KT; Malawska, B; Kulig, K Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice. Eur J Med Chem188:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium- and chloride-dependent GABA transporter 2 |
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| Name: | Sodium- and chloride-dependent GABA transporter 2 |
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| Synonyms: | GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68283.40 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1460089 |
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| Residue: | 602 |
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| Sequence: | MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPY
LCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQM
IVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENAT
SPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATF
PYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTAL
GSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFI
AYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLI
LIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNI
EDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALS
SMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELES
NC
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| BDBM50039248 |
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| n/a |
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| Name | BDBM50039248 |
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| Synonyms: | (R)-1-{2-[Tris-(4-methoxy-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid | CHEMBL419823 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H35NO6 |
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| Mol. Mass. | 505.602 |
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| SMILES | COc1ccc(cc1)C(OCCN1CCC[C@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1 |
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| Structure | 
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