| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melatonin receptor type 1B |
|---|
| Ligand | BDBM50564115 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2086567 (CHEMBL4767830) |
|---|
| Ki | 110±n/a nM |
|---|
| Citation |  Herrera-Arozamena, C; Estrada-Valencia, M; Pérez, C; Lagartera, L; Morales-García, JA; Pérez-Castillo, A; Franco-Gonzalez, JF; Michalska, P; Duarte, P; León, R; López, MG; Mills, A; Gago, F; García-Yagüe, ÁJ; Fernández-Ginés, R; Cuadrado, A; Rodríguez-Franco, MI Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties. Eur J Med Chem190:0 (2020) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melatonin receptor type 1B |
|---|
| Name: | Melatonin receptor type 1B |
|---|
| Synonyms: | MTNR1B | MTR1B_HUMAN | Mel-1B-R | Mel1b melatonin receptor | Melatonin 1B | Melatonin receptor | Melatonin receptor type 1B | Melatonin receptor type 2 (MT2) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 40203.54 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P49286 |
|---|
| Residue: | 362 |
|---|
| Sequence: | MSENGSFANCCEAGGWAVRPGWSGAGSARPSRTPRPPWVAPALSAVLIVTTAVDVVGNLL
VILSVLRNRKLRNAGNLFLVSLALADLVVAFYPYPLILVAIFYDGWALGEEHCKASAFVM
GLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHICLIWLLTVVALLPNFFVGS
LEYDPRIYSCTFIQTASTQYTAAVVVIHFLLPIAVVSFCYLRIWVLVLQARRKAKPESRL
CLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVAINPQEMAPQIPEGLFVTSYLLAYFN
SCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQDASKGSHAEGLQSPAPPIIGVQHQAD
AL
|
|
|
|---|
| BDBM50564115 |
|---|
| n/a |
|---|
| Name | BDBM50564115 |
|---|
| Synonyms: | CHEMBL4794879 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H16N4O2 |
|---|
| Mol. Mass. | 272.3024 |
|---|
| SMILES | CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
