| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase pim-1 |
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| Ligand | BDBM50565166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2090879 (CHEMBL4772142) |
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| IC50 | >10000±n/a nM |
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| Citation |  Benchekroun, M; Ermolenko, L; Tran, MQ; Vagneux, A; Nedev, H; Delehouzé, C; Souab, M; Baratte, B; Josselin, B; Iorga, BI; Ruchaud, S; Bach, S; Al-Mourabit, A Discovery of simplified benzazole fragments derived from the marine benzosceptrin B as necroptosis inhibitors involving the receptor interacting protein Kinase-1. Eur J Med Chem201:0 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase pim-1 |
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| Name: | Serine/threonine-protein kinase pim-1 |
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| Synonyms: | PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) |
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| Type: | Protein |
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| Mol. Mass.: | 35681.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11309 |
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| Residue: | 313 |
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| Sequence: | MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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| BDBM50565166 |
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| n/a |
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| Name | BDBM50565166 |
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| Synonyms: | CHEMBL4776698 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H14N4O2 |
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| Mol. Mass. | 234.2545 |
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| SMILES | CCCCNc1nc2ccc(cc2[nH]1)[N+]([O-])=O |
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| Structure | 
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