Reaction Details |
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Target | G protein-coupled receptor kinase 5 |
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Ligand | BDBM50566206 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2094573 (CHEMBL4775836) |
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Ki | 19±n/a nM |
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Citation | Rowlands, RA; Chen, Q; Bouley, RA; Avramova, LV; Tesmer, JJG; White, AD Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem64:566-585 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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G protein-coupled receptor kinase 5 |
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Name: | G protein-coupled receptor kinase 5 |
Synonyms: | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5 | GRK5_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 67798.93 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1280627 |
Residue: | 590 |
Sequence: | MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHISQCEDLRRTIDRDYCSLCDKQ
PIGRLLFRQFCETRPGLECYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFIAQ
VGQDLVSQTEEKLLQKPCKELFSACAQSVHEYLRGEPFHEYLDSMFFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRN
HPPEPPKKGLLQRLFKRQHQNNSKSSPSSKTSFNHHINSNHVSSNSTGSS
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BDBM50566206 |
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n/a |
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Name | BDBM50566206 |
Synonyms: | CHEMBL4786599 |
Type | Small organic molecule |
Emp. Form. | C27H26ClFN4O3 |
Mol. Mass. | 508.972 |
SMILES | C[C@H](Cc1ccc(F)cc1)NC(=O)c1ccc2NC(=O)\C(=C/c3[nH]c(C)c(NC(=O)CCl)c3C)c2c1 |r| |
Structure |
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