Ki Summary

Reaction Details

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Target

Gastric inhibitory polypeptide receptor

Ligand

BDBM50566469

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2100497 (CHEMBL4808893)

IC50

>1000±n/a nM

Citation

Yang, B; Gelfanov, VM; Perez-Tilve, D; DuBois, B; Rohlfs, R; Levy, J; Douros, JD; Finan, B; Mayer, JP; DiMarchi, RD Optimization of Truncated Glucagon Peptides to Achieve Selective, High Potency, Full Antagonists. J Med Chem64:4697-4708 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastric inhibitory polypeptide receptor

Name:

Gastric inhibitory polypeptide receptor

Synonyms:

GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor

Type:

PROTEIN

Mol. Mass.:

53173.82

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1518286

Residue:

466

Sequence:

MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC

BDBM50566469

n/a

Name

BDBM50566469

Synonyms:

CHEMBL4876736

Type

Small organic molecule

Emp. Form.

C133H194N34O42S

Mol. Mass.

2973.231

SMILES

CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](O)Cc1ccccc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r|

Structure