Reaction Details |
| Report a problem with these data |
Target | G protein-coupled receptor kinase 4 |
---|
Ligand | BDBM50566947 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2102046 (CHEMBL4810442) |
---|
IC50 | 190±n/a nM |
---|
Citation | Uehling, DE; Joseph, B; Chung, KC; Zhang, AX; Ler, S; Prakesch, MA; Poda, G; Grouleff, J; Aman, A; Kiyota, T; Leung-Hagesteijn, C; Konda, JD; Marcellus, R; Griffin, C; Subramaniam, R; Abibi, A; Strathdee, CA; Isaac, MB; Al-Awar, R; Tiedemann, RE Design, Synthesis, and Characterization of 4-Aminoquinazolines as Potent Inhibitors of the G Protein-Coupled Receptor Kinase 6 (GRK6) for the Treatment of Multiple Myeloma. J Med Chem64:11129-11147 (2021) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
G protein-coupled receptor kinase 4 |
---|
Name: | G protein-coupled receptor kinase 4 |
Synonyms: | GPRK2L | GPRK4 | GRK4 | GRK4_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 66590.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_774219 |
Residue: | 578 |
Sequence: | MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ
PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE
IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ
PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE
KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL
EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN
EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI
CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD
IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK
NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC
|
|
|
BDBM50566947 |
---|
n/a |
---|
Name | BDBM50566947 |
Synonyms: | CHEMBL4847703 |
Type | Small organic molecule |
Emp. Form. | C20H20FN7O |
Mol. Mass. | 393.4175 |
SMILES | CCc1cc(Nc2nc(NCc3ccc(F)cn3)nc3cccc(OC)c23)n[nH]1 |
Structure |
|