| Reaction Details |
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 | Report a problem with these data |
| Target | Peroxisome proliferator-activated receptor alpha |
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| Ligand | BDBM50131502 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_153406 |
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| IC50 | 47±n/a nM |
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| Citation |  Desai, RC; Han, W; Metzger, EJ; Bergman, JP; Gratale, DF; MacNaul, KL; Berger, JP; Doebber, TW; Leung, K; Moller, DE; Heck, JV; Sahoo, SP 5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents. Bioorg Med Chem Lett13:2795-8 (2003) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Peroxisome proliferator-activated receptor alpha |
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| Name: | Peroxisome proliferator-activated receptor alpha |
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| Synonyms: | NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52222.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07869 |
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| Residue: | 468 |
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| Sequence: | MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSC
PGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACE
GCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSE
KAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFV
IHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFD
FAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDI
FLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
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| BDBM50131502 |
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| n/a |
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| Name | BDBM50131502 |
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| Synonyms: | 5-{3-[3-(4-Phenoxy-phenoxy)-propoxy]-phenyl}-thiazolidine-2,4-dione | CHEMBL1783034 | CHEMBL96107 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21NO5S |
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| Mol. Mass. | 435.492 |
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| SMILES | Oc1[nH]c(=O)sc1-c1cccc(OCCCOc2ccc(Oc3ccccc3)cc2)c1 |
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| Structure | 
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