Reaction Details |
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Target | Thyroid peroxidase |
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Ligand | BDBM50567717 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2103814 (CHEMBL4812317) |
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IC50 | 1100±n/a nM |
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Citation | Hu, CH; Neissel Valente, MW; Halpern, OS; Jusuf, S; Khan, JA; Locke, GA; Duke, GJ; Liu, X; Duclos, FJ; Wexler, RR; Kick, EK; Smallheer, JM Small molecule and macrocyclic pyrazole derived inhibitors of myeloperoxidase (MPO). Bioorg Med Chem Lett42:0 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid peroxidase |
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Name: | Thyroid peroxidase |
Synonyms: | PERT_HUMAN | TPO | Thyroid peroxidase | Thyroid peroxidase (TPO) |
Type: | Enzyme |
Mol. Mass.: | 102965.07 |
Organism: | Homo sapiens (Human) |
Description: | P07202 |
Residue: | 933 |
Sequence: | MRALAVLSVTLVMACTEAFFPFISRGKELLWGKPEESRVSSVLEESKRLVDTAMYATMQR
NLKKRGILSPAQLLSFSKLPEPTSGVIARAAEIMETSIQAMKRKVNLKTQQSQHPTDALS
EDLLSIIANMSGCLPYMLPPKCPNTCLANKYRPITGACNNRDHPRWGASNTALARWLPPV
YEDGFSQPRGWNPGFLYNGFPLPPVREVTRHVIQVSNEVVTDDDRYSDLLMAWGQYIDHD
IAFTPQSTSKAAFGGGADCQMTCENQNPCFPIQLPEEARPAAGTACLPFYRSSAACGTGD
QGALFGNLSTANPRQQMNGLTSFLDASTVYGSSPALERQLRNWTSAEGLLRVHARLRDSG
RAYLPFVPPRAPAACAPEPGIPGETRGPCFLAGDGRASEVPSLTALHTLWLREHNRLAAA
LKALNAHWSADAVYQEARKVVGALHQIITLRDYIPRILGPEAFQQYVGPYEGYDSTANPT
VSNVFSTAAFRFGHATIHPLVRRLDASFQEHPDLPGLWLHQAFFSPWTLLRGGGLDPLIR
GLLARPAKLQVQDQLMNEELTERLFVLSNSSTLDLASINLQRGRDHGLPGYNEWREFCGL
PRLETPADLSTAIASRSVADKILDLYKHPDNIDVWLGGLAENFLPRARTGPLFACLIGKQ
MKALRDGDWFWWENSHVFTDAQRRELEKHSLSRVICDNTGLTRVPMDAFQVGKFPEDFES
CDSITGMNLEAWRETFPQDDKCGFPESVENGDFVHCEESGRRVLVYSCRHGYELQGREQL
TCTQEGWDFQPPLCKDVNECADGAHPPCHASARCRNTKGGFQCLCADPYELGDDGRTCVD
SGRLPRVTWISMSLAALLIGGFAGLTSTVICRWTRTGTKSTLPISETGGGTPELRCGKHQ
AVGTSPQRAAAQDSEQESAGMEGRDTHRLPRAL
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BDBM50567717 |
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n/a |
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Name | BDBM50567717 |
Synonyms: | CHEMBL4853722 |
Type | Small organic molecule |
Emp. Form. | C20H17N7 |
Mol. Mass. | 355.3959 |
SMILES | Nc1cc(Cc2ccn(Cc3ccc4ccccc4c3)n2)c2nn[nH]c2n1 |
Structure |
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