| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carbapenem-hydrolyzing beta-lactamase KPC |
|---|
| Ligand | BDBM50569702 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2109934 (CHEMBL4818609) |
|---|
| Ki | 3690±n/a nM |
|---|
| Citation |  Romero, E; Oueslati, S; Benchekroun, M; D'Hollander, ACA; Ventre, S; Vijayakumar, K; Minard, C; Exilie, C; Tlili, L; Retailleau, P; Zavala, A; Elisée, E; Selwa, E; Nguyen, LA; Pruvost, A; Naas, T; Iorga, BI; Dodd, RH; Cariou, K Azetidinimines as a novel series of non-covalent broad-spectrum inhibitors of ?-lactamases with submicromolar activities against carbapenemases KPC-2 (class A), NDM-1 (class B) and OXA-48 (class D). Eur J Med Chem219:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carbapenem-hydrolyzing beta-lactamase KPC |
|---|
| Name: | Carbapenem-hydrolyzing beta-lactamase KPC |
|---|
| Synonyms: | BLKPC_KLEOX | Carbapenem-hydrolyzing beta-lactamase KPC-2 | bla | kpc | kpc2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 31116.99 |
|---|
| Organism: | n/a |
|---|
| Description: | Q848S6 |
|---|
| Residue: | 293 |
|---|
| Sequence: | MSLYRRLVLLSCLSWPLAGFSATALTNLVAEPFAKLEQDFGGSIGVYAMDTGSGATVSYR
AEERFPLCSSFKGFLAAAVLARSQQQAGLLDTPIRYGKNALVPWSPISEKYLTTGMTVAE
LSAAAVQYSDNAAANLLLKELGGPAGLTAFMRSIGDTTFRLDRWELELNSAIPGDARDTS
SPRAVTESLQKLTLGSALAAPQRQQFVDWLKGNTTGNHRIRAAVPADWAVGDKTGTCGVY
GTANDYAVVWPTGRAPIVLAVYTRAPNKDDKHSEAVIAAAARLALEGLGVNGQ
|
|
|
|---|
| BDBM50569702 |
|---|
| n/a |
|---|
| Name | BDBM50569702 |
|---|
| Synonyms: | CHEMBL4864325 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H21Cl2IN2O |
|---|
| Mol. Mass. | 599.29 |
|---|
| SMILES | Clc1ccc(C2C\C(=N/c3ccc(I)cc3)N2c2ccc(OCc3ccccc3)cc2)c(Cl)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
