| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum aminopeptidase 1 |
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| Ligand | BDBM50077017 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2111181 (CHEMBL4820031) |
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| IC50 | 11000±n/a nM |
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| Citation |  Laura, M; Ronan, G; Vy, LB; Valentin, G; Omar, CA; Virgyl, C; Piveteau, C; Melissa, R; Charlotte, F; Sandrine, W; Julie, C; Julie, DR; Damien, B; Florence, L; Peter, VE; Benoit, D; Rebecca, DP Modulators of hERAP2 discovered by high-throughput screening. Eur J Med Chem211:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum aminopeptidase 1 |
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| Name: | Endoplasmic reticulum aminopeptidase 1 |
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| Synonyms: | APPILS | ARTS1 | Aminopeptidase | ERAP1 | ERAP1_HUMAN | KIAA0525 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 107232.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473167 |
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| Residue: | 941 |
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| Sequence: | MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIP
VHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPL
QVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILAST
QFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTV
KMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP
YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWF
GNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVS
TPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWD
SMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGR
NVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKF
NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDL
SLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEG
SVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTE
GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIG
RNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE
NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM
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| BDBM50077017 |
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| n/a |
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| Name | BDBM50077017 |
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| Synonyms: | CHEMBL3416725 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N4O5 |
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| Mol. Mass. | 442.5081 |
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| SMILES | CCCC[C@H](N)C(=O)Nc1ccc(cc1N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC |r| |
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| Structure | 
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