| Reaction Details |
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 | Report a problem with these data |
| Target | Calcitonin gene-related peptide 2 |
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| Ligand | BDBM50570391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2112109 (CHEMBL4820959) |
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| IC50 | 3162±n/a nM |
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| Citation |  Zirimwabagabo, JO; Jailani, ABA; Avgoustou, P; Tozer, MJ; Gibson, KR; Glossop, PA; Mills, JEJ; Porter, RA; Blaney, P; Wang, N; Skerry, TM; Richards, GO; Harrity, JPA Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization. J Med Chem64:3299-3319 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcitonin gene-related peptide 2 |
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| Name: | Calcitonin gene-related peptide 2 |
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| Synonyms: | Beta-CGRP | Beta-type CGRP | CALC2 | CALCB | CALCB_HUMAN | CGRP-II | Calcitonin gene-related peptide II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 13714.13 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_116903 |
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| Residue: | 127 |
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| Sequence: | MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQM
KASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGR
RRRDLQA
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| BDBM50570391 |
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| n/a |
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| Name | BDBM50570391 |
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| Synonyms: | CHEMBL4876213 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N5O3 |
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| Mol. Mass. | 503.6358 |
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| SMILES | CN1CCCC(CN(CC(=O)Nc2ccc3CC4(Cc3c2)C(=O)Nc2ncccc42)C(=O)C(C)(C)C)C1 |
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| Structure | 
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