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TargetCalcitonin gene-related peptide 2
LigandBDBM50570402
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2112109 (CHEMBL4820959)
IC50 126±n/a nM
Citation Zirimwabagabo, JOJailani, ABAAvgoustou, PTozer, MJGibson, KRGlossop, PAMills, JEJPorter, RABlaney, PWang, NSkerry, TMRichards, GOHarrity, JPA Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure-Activity Relationships and Optimization. J Med Chem64:3299-3319 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcitonin gene-related peptide 2
Name:Calcitonin gene-related peptide 2
Synonyms:Beta-CGRP | Beta-type CGRP | CALC2 | CALCB | CALCB_HUMAN | CGRP-II | Calcitonin gene-related peptide II
Type:PROTEIN
Mol. Mass.:13714.13
Organism:Homo sapiens
Description:ChEMBL_116903
Residue:127
Sequence:
MGFRKFSPFLALSILVLYQAGSLQAAPFRSALESSPDPATLSKEDARLLLAALVQDYVQM
KASELKQEQETQGSSSAAQKRACNTATCVTHRLAGLLSRSGGMVKSNFVPTNVGSKAFGR
RRRDLQA
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BDBM50570402
n/a
NameBDBM50570402
Synonyms:CHEMBL4856402
TypeSmall organic molecule
Emp. Form.C32H35N5O3
Mol. Mass.537.652
SMILESCC(C)(C)C(=O)N(CC(=O)Nc1ccc2CC3(Cc2c1)C(=O)Nc1ncccc31)Cc1cccc2CCNCc12
Structure
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