Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50570415

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2112153 (CHEMBL4821003)

EC50

330±n/a nM

Citation

Johnson, JA; Kim, SH; Jiang, J; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; He, Y; Chen, XQ; Xu, C; Galella, MA; Wang, T; Gordon, DA; Wexler, RR; Finlay, HJ Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. J Med Chem64:3086-3099 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50570415

n/a

Name

BDBM50570415

Synonyms:

CHEMBL4873340

Type

Small organic molecule

Emp. Form.

C26H28N4O4

Mol. Mass.

460.5249

SMILES

CCCCc1[nH]c(=O)c(-c2n[nH]c(Cc3ccccc3)n2)c(O)c1-c1c(OC)cccc1OC |(13.71,-4.63,;15.04,-5.39,;16.37,-4.61,;17.71,-5.37,;19.04,-4.6,;19.03,-3.06,;20.37,-2.28,;20.36,-.74,;21.7,-3.04,;23.03,-2.27,;23.19,-.74,;24.69,-.41,;25.47,-1.75,;27,-1.9,;27.63,-3.31,;26.72,-4.55,;27.35,-5.96,;28.88,-6.11,;29.79,-4.86,;29.15,-3.46,;24.44,-2.89,;21.71,-4.58,;23.04,-5.36,;20.37,-5.36,;20.38,-6.89,;19.05,-7.66,;17.72,-6.9,;16.39,-7.67,;19.05,-9.21,;20.39,-9.98,;21.72,-9.2,;21.72,-7.65,;23.05,-6.88,;24.38,-7.65,)|

Structure