Ki Summary

Reaction Details

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Target

Apelin receptor

Ligand

BDBM50570417

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2112153 (CHEMBL4821003)

EC50

13±n/a nM

Citation

Johnson, JA; Kim, SH; Jiang, J; Phillips, M; Schumacher, WA; Bostwick, JS; Gargalovic, PS; Onorato, JM; Luk, CE; Generaux, C; He, Y; Chen, XQ; Xu, C; Galella, MA; Wang, T; Gordon, DA; Wexler, RR; Finlay, HJ Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate. J Med Chem64:3086-3099 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Apelin receptor

Name:

Apelin receptor

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

42664.06

Organism:

Homo sapiens (Human)

Description:

P35414

Residue:

380

Sequence:

MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD

BDBM50570417

n/a

Name

BDBM50570417

Synonyms:

CHEMBL4858384

Type

Small organic molecule

Emp. Form.

C26H27N3O5

Mol. Mass.

461.5097

SMILES

CCCCc1[nH]c(=O)c(-c2nnc(Cc3ccccc3)o2)c(O)c1-c1c(OC)cccc1OC |(48.64,-5.04,;49.98,-5.8,;51.31,-5.02,;52.65,-5.79,;53.98,-5.01,;53.97,-3.47,;55.3,-2.69,;55.3,-1.15,;56.64,-3.46,;57.97,-2.68,;58.13,-1.15,;59.63,-.83,;60.41,-2.16,;61.94,-2.31,;62.57,-3.72,;61.66,-4.96,;62.29,-6.37,;63.82,-6.53,;64.73,-5.27,;64.09,-3.87,;59.38,-3.3,;56.65,-5,;57.98,-5.77,;55.31,-5.77,;55.32,-7.3,;53.99,-8.07,;52.66,-7.31,;51.33,-8.08,;53.99,-9.62,;55.32,-10.39,;56.66,-9.62,;56.66,-8.07,;57.99,-7.3,;59.32,-8.06,)|

Structure