| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum aminopeptidase 1 |
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| Ligand | BDBM50570851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2113192 (CHEMBL4822042) |
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| IC50 | 330±n/a nM |
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| Citation |  Wilding, B; Pasqua, AE; E A Chessum, N; Pierrat, OA; Hahner, T; Tomlin, K; Shehu, E; Burke, R; Richards, GM; Whitton, B; Arwert, EN; Thapaliya, A; Salimraj, R; van Montfort, R; Skawinska, A; Hayes, A; Raynaud, F; Chopra, R; Jones, K; Newton, G; Cheeseman, MD Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1. Bioorg Med Chem Lett42:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum aminopeptidase 1 |
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| Name: | Endoplasmic reticulum aminopeptidase 1 |
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| Synonyms: | APPILS | ARTS1 | Aminopeptidase | ERAP1 | ERAP1_HUMAN | KIAA0525 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 107232.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473167 |
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| Residue: | 941 |
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| Sequence: | MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIP
VHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPL
QVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILAST
QFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTV
KMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP
YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWF
GNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVS
TPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWD
SMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGR
NVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKF
NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDL
SLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEG
SVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTE
GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIG
RNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE
NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM
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| BDBM50570851 |
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| n/a |
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| Name | BDBM50570851 |
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| Synonyms: | CHEMBL4853049 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N3O3P |
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| Mol. Mass. | 469.5561 |
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| SMILES | CC(C)C[C@H](CP(O)(=O)[C@@H](N)CCc1ccccc1)C(=O)NCCc1c[nH]c2ccccc12 |r| |
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| Structure | 
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