| Reaction Details |
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 | Report a problem with these data |
| Target | 60 kDa heat shock protein, mitochondrial |
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| Ligand | BDBM50571160 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2114004 (CHEMBL4822854) |
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| IC50 | 24000±n/a nM |
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| Citation |  Ray, AM; Salim, N; Stevens, M; Chitre, S; Abdeen, S; Washburn, A; Sivinski, J; O'Hagan, HM; Chapman, E; Johnson, SM Exploiting the HSP60/10 chaperonin system as a chemotherapeutic target for colorectal cancer. Bioorg Med Chem40:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 60 kDa heat shock protein, mitochondrial |
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| Name: | 60 kDa heat shock protein, mitochondrial |
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| Synonyms: | 3.6.4.9 | 60 kDa chaperonin | 60 kDa heat shock protein, mitochondrial | CH60_HUMAN | CPN60 | Chaperonin 60 | HSP-60 | HSP60 | HSP60/HSP10 | HSPD1 | Heat shock protein 60 | HuCHA60 | Mitochondrial matrix protein P1 | P60 lymphocyte protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61050.41 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_117701 |
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| Residue: | 573 |
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| Sequence: | MLRLPTVFRQMRPVSRVLAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGR
TVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLA
RSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDK
EIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQ
DAYVLLSEKKISSIQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAV
KAPGFGDNRKNQLKDMAIATGGAVFGEEGLTLNLEDVQPHDLGKVGEVIVTKDDAMLLKG
KGDKAQIEKRIQEIIEQLDVTTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDR
VTDALNATRAAVEEGIVLGGGCALLRCIPALDSLTPANEDQKIGIEIIKRTLKIPAMTIA
KNAGVEGSLIVEKIMQSSSEVGYDAMAGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLT
TAEVVVTEIPKEEKDPGMGAMGGMGGGMGGGMF
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| BDBM50571160 |
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| n/a |
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| Name | BDBM50571160 |
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| Synonyms: | CHEMBL4858760 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H28N4O6S |
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| Mol. Mass. | 548.61 |
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| SMILES | COc1ccc(cc1)S(=O)(=O)Nc1ccc2oc(nc2c1)-c1ccc(NC(=O)C2CCN(CC2)C(C)=O)cc1 |
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| Structure | 
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