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TargetGlycogen synthase kinase-3 beta
LigandBDBM50166940
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2114091 (CHEMBL4822941)
IC50 1780±n/a nM
Citation Ghazanfari, D; Noori, MS; Bergmeier, SC; Hines, JV; McCall, KD; Goetz, DJ A novel GSK-3 inhibitor binds to GSK-3? via a reversible, time and Cys-199-dependent mechanism. Bioorg Med Chem40:0 (2021) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM50166940
n/a
NameBDBM50166940
Synonyms:NP-031112 | NP-12 | Tideglusib | US20230414581, Compound 7 | med.21724, Compound 155
TypeSmall organic molecule
Emp. Form.C19H14N2O2S
Mol. Mass.334.392
SMILESO=c1sn(-c2cccc3ccccc23)c(=O)n1Cc1ccccc1
Structure
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