Ki Summary

Reaction Details

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Target

P2Y purinoceptor 6

Ligand

BDBM50271102

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_2114154 (CHEMBL4823004)

EC50

700±n/a nM

Citation

Oliva, P; Scortichini, M; Dobelmann, C; Jain, S; Gopinatth, V; Toti, KS; Phung, NB; Junker, A; Jacobson, KA Structure-activity relationships of pyrimidine nucleotides containing a 5'-?,?-methylene diphosphonate at the P2Y Bioorg Med Chem Lett45:0 (2021) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

P2Y purinoceptor 6

Name:

P2Y purinoceptor 6

Synonyms:

P2RY6 | P2RY6_HUMAN | P2Y purinoceptor 6 | P2Y6 | Pyrimidinergic receptor P2Y6

Type:

PROTEIN

Mol. Mass.:

36452.29

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1511151

Residue:

328

Sequence:

MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLNICVITQICTSRRALTR
TAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLVRFLFYANLHGSILFLTCI
SFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCLPTAIFAATGIQRNRTVCYDL
SPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACRLCRQDGPAEPVAQERRGKAARM
AVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVLEAFAAAYKGTRPFASANSVLDPIL
FYFTQKKFRRRPHELLQKLTAKWQRQGR

BDBM50271102

n/a

Name

BDBM50271102

Synonyms:

((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)methylphosphonic acid | 5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE | CHEMBL507060 | Uridine-5'-alpha,beta-methylene-diphosphate | {[(2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]-hydroxy-phosphorylmethyl}-phosphonic acid

Type

Small organic molecule

Emp. Form.

C10H16N2O11P2

Mol. Mass.

402.1884

SMILES

O[C@@H]1[C@@H](COP(O)(=O)CP(O)(O)=O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O |r|

Structure