| Reaction Details |
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 | Report a problem with these data |
| Target | Endoplasmic reticulum aminopeptidase 1 |
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| Ligand | BDBM50571864 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2115914 (CHEMBL4824855) |
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| IC50 | 1119±n/a nM |
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| Citation |  Deddouche-Grass, S; Andouche, C; Bärenz, F; Halter, C; Hohwald, A; Lebrun, L; Membré, N; Morales, R; Muzet, N; Poirot, M; Reynaud, M; Roujean, V; Weber, F; Zimmermann, A; Heng, R; Basse, N Discovery and Optimization of a Series of Benzofuran Selective ERAP1 Inhibitors: Biochemical and ACS Med Chem Lett12:1137-1142 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endoplasmic reticulum aminopeptidase 1 |
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| Name: | Endoplasmic reticulum aminopeptidase 1 |
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| Synonyms: | APPILS | ARTS1 | Aminopeptidase | ERAP1 | ERAP1_HUMAN | KIAA0525 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 107232.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473167 |
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| Residue: | 941 |
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| Sequence: | MVFLPLKWSLATMSFLLSSLLALLTVSTPSWCQSTEASPKRSDGTPFPWNKIRLPEYVIP
VHYDLLIHANLTTLTFWGTTKVEITASQPTSTIILHSHHLQISRATLRKGAGERLSEEPL
QVLEHPRQEQIALLAPEPLLVGLPYTVVIHYAGNLSETFHGFYKSTYRTKEGELRILAST
QFEPTAARMAFPCFDEPAFKASFSIKIRREPRHLAISNMPLVKSVTVAEGLIEDHFDVTV
KMSTYLVAFIISDFESVSKITKSGVKVSVYAVPDKINQADYALDAAVTLLEFYEDYFSIP
YPLPKQDLAAIPDFQSGAMENWGLTTYRESALLFDAEKSSASSKLGITMTVAHELAHQWF
GNLVTMEWWNDLWLNEGFAKFMEFVSVSVTHPELKVGDYFFGKCFDAMEVDALNSSHPVS
TPVENPAQIREMFDDVSYDKGACILNMLREYLSADAFKSGIVQYLQKHSYKNTKNEDLWD
SMASICPTDGVKGMDGFCSRSQHSSSSSHWHQEGVDVKTMMNTWTLQKGFPLITITVRGR
NVHMKQEHYMKGSDGAPDTGYLWHVPLTFITSKSDMVHRFLLKTKTDVLILPEEVEWIKF
NVGMNGYYIVHYEDDGWDSLTGLLKGTHTAVSSNDRASLINNAFQLVSIGKLSIEKALDL
SLYLKHETEIMPVFQGLNELIPMYKLMEKRDMNEVETQFKAFLIRLLRDLIDKQTWTDEG
SVSERMLRSQLLLLACVHNYQPCVQRAEGYFRKWKESNGNLSLPVDVTLAVFAVGAQSTE
GWDFLYSKYQFSLSSTEKSQIEFALCRTQNKEKLQWLLDESFKGDKIKTQEFPQILTLIG
RNPVGYPLAWQFLRKNWNKLVQKFELGSSSIAHMVMGTTNQFSTRTRLEEVKGFFSSLKE
NGSQLRCVQQTIETIEENIGWMDKNFDKIRVWLQSEKLERM
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| BDBM50571864 |
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| n/a |
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| Name | BDBM50571864 |
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| Synonyms: | CHEMBL4853997 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H13ClFNO4 |
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| Mol. Mass. | 373.762 |
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| SMILES | OC(=O)C1(CC1)NC(=O)c1cc(F)cc2cc(oc12)-c1ccc(Cl)cc1 |
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| Structure | 
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