| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Ligand | BDBM68853 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2116453 (CHEMBL4825394) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Tsai, WC; Gilbert, NC; Ohler, A; Armstrong, M; Perry, S; Kalyanaraman, C; Yasgar, A; Rai, G; Simeonov, A; Jadhav, A; Standley, M; Lee, HW; Crews, P; Iavarone, AT; Jacobson, MP; Neau, DB; Offenbacher, AR; Newcomer, M; Holman, TR Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2. Bioorg Med Chem46:0 (2021) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Name: | Polyunsaturated fatty acid 5-lipoxygenase |
|---|
| Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | 5-lipoxygenase/FLAP | ALOX5 | Arachidonate 5-lipoxygenase | LOG5 | LOX5_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 77972.74 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
|
|---|
| Residue: | 674 |
|---|
| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLA
RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNG
CNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG
LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWE
AIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPY
YYLSPDRIPNSVAI
|
|
|
|---|
| BDBM68853 |
|---|
| n/a |
|---|
| Name | BDBM68853 |
|---|
| Synonyms: | 1-phenyl-2-[[4-(trifluoromethyl)benzyl]thio]imidazole | 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylsulfanyl]imidazole | 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole | 1-phenyl-2-{[4-(trifluoromethyl)benzyl]sulfanyl}-1H-imidazole | MLS000327069 | SMR000179722 | cid_3696046 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H13F3N2S |
|---|
| Mol. Mass. | 334.359 |
|---|
| SMILES | FC(F)(F)c1ccc(CSc2nccn2-c2ccccc2)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
