| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-C/Cyclin-dependent kinase 19 |
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| Ligand | BDBM50573482 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119598 (CHEMBL4828664) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Hatcher, JM; Vatsan, PS; Wang, E; Jiang, J; Gray, NS Development of Highly Potent and Selective Pyrazolopyridine Inhibitor of CDK8/19. ACS Med Chem Lett12:1689-1693 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-C/Cyclin-dependent kinase 19 |
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| Name: | Cyclin-C/Cyclin-dependent kinase 19 |
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| Synonyms: | CDK19/Cyclin C |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Cyclin-dependent kinase 19 |
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| Synonyms: | CDC2-related protein kinase 6 | CDC2L6 | CDK11 | CDK19 | CDK19_HUMAN | Cell division cycle 2-like protein kinase 6 | Cell division protein kinase 19 | Cyclin-dependent kinase 11 | Death-preventing kinase | KIAA1028 |
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| Type: | Serine/Threonine protein kinase |
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| Mol. Mass.: | 56816.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BWU1 |
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| Residue: | 502 |
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| Sequence: | MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGIS
MSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKP
MQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKH
KVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLN
EDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTG
AGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQST
LGYSSSSQQSSQYHPSHQAHRY
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| Component 2 |
| Name: | Cyclin-C |
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| Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 33244.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_107900 |
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| Residue: | 283 |
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| Sequence: | MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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| BDBM50573482 |
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| n/a |
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| Name | BDBM50573482 |
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| Synonyms: | CHEMBL4858092 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23ClN6O |
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| Mol. Mass. | 434.921 |
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| SMILES | Cn1ncc2cc(ccc12)-c1cnc2[nH]cc(Cl)c2c1N1CCC2(CCNC2=O)CC1 |
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| Structure | 
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