| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1D |
|---|
| Ligand | BDBM50139515 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1716 |
|---|
| Ki | 29±n/a nM |
|---|
| Citation |  Egle, I; MacLean, N; Demchyshyn, L; Edwards, L; Slassi, A; Tehim, A 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands. Bioorg Med Chem Lett14:727-9 (2004) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 1D |
|---|
| Name: | 5-hydroxytryptamine receptor 1D |
|---|
| Synonyms: | 5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 41920.63 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Receptor binding assays were performed using human clone stably expressed in CHO cells. |
|---|
| Residue: | 377 |
|---|
| Sequence: | MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS
|
|
|
|---|
| BDBM50139515 |
|---|
| n/a |
|---|
| Name | BDBM50139515 |
|---|
| Synonyms: | Adamantane-1-carboxylic acid {4-[3-(2-pyrrolidin-1-yl-ethyl)-1H-indol-5-yl]-3,6-dihydro-2H-pyridin-1-yl}-amide | CHEMBL440008 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H40N4O |
|---|
| Mol. Mass. | 472.6648 |
|---|
| SMILES | O=C(NN1CCC(=CC1)c1ccc2[nH]cc(CCN3CCCC3)c2c1)C12CC3CC(CC(C3)C1)C2 |c:6,TLB:28:29:33:26.27.32,THB:28:27:33:34.29.30,30:31:26:34.29.28,30:29:26:33.31.32| |
|---|
| Structure | 
|
|---|
Search and Browse
