| Reaction Details |
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 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 2 |
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| Ligand | BDBM50573632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2119950 (CHEMBL4829097) |
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| IC50 | 16±n/a nM |
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| Citation |  Xia, B; Franklin, GJ; Lu, X; Bedard, KL; Grady, LC; Summerfield, JD; Shi, EX; King, BW; Lind, KE; Chiu, C; Watts, E; Bodmer, V; Bai, X; Marcaurelle, LA DNA-Encoded Library Hit Confirmation: Bridging the Gap Between On-DNA and Off-DNA Chemistry. ACS Med Chem Lett12:1166-1172 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Receptor-interacting serine/threonine-protein kinase 2 |
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| Name: | Receptor-interacting serine/threonine-protein kinase 2 |
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| Synonyms: | CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2 |
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| Type: | Protein |
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| Mol. Mass.: | 61201.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 540 |
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| Sequence: | MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSER
KDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPL
RFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRS
SKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMY
SVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEI
TFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPET
SRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIIN
PLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTK
PTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
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| BDBM50573632 |
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| n/a |
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| Name | BDBM50573632 |
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| Synonyms: | CHEMBL4876135 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15N3S |
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| Mol. Mass. | 353.44 |
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| SMILES | N(c1ccc2scnc2c1)c1ccnc2cc(ccc12)-c1ccccc1 |
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| Structure | 
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