| Reaction Details |
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 | Report a problem with these data |
| Target | Monoglyceride lipase |
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| Ligand | BDBM50574641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2122937 (CHEMBL4832170) |
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| IC50 | 14±n/a nM |
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| Citation |  Bononi, G; Tonarini, G; Poli, G; Barravecchia, I; Caligiuri, I; Macchia, M; Rizzolio, F; Demontis, GC; Minutolo, F; Granchi, C; Tuccinardi, T Monoacylglycerol lipase (MAGL) inhibitors based on a diphenylsulfide-benzoylpiperidine scaffold. Eur J Med Chem223:0 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Monoglyceride lipase |
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| Name: | Monoglyceride lipase |
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| Synonyms: | HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN |
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| Type: | Hydrolase |
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| Mol. Mass.: | 33264.56 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant MGL (Cayman Chemical, cat# 10008354). |
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| Residue: | 303 |
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| Sequence: | MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
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| BDBM50574641 |
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| n/a |
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| Name | BDBM50574641 |
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| Synonyms: | CHEMBL4871592 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21F2NO3S |
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| Mol. Mass. | 453.501 |
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| SMILES | Oc1cccc(c1)C(=O)N1CCC(CC1)C(=O)c1ccc(Sc2ccc(F)c(F)c2)cc1 |
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| Structure | 
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